Donor Exclusion Criteria and Tests Performed

Table : Exclusion Criteria and Tests Performed

History/Examination

Between 18 and 35 years of age

Any medications

Antibiotics, antifungals, or antivirals in the last 3 months

Probiotics in the last 3 months

Hospitalization in the last 3 months

Travel to high-risk areas of infectious diarrhea in the last 3 months

Acute diarrhea within the past 6 months

Tattoo or body piercing in the last 6 months

Known HIV or viral hepatitis exposure in the last 12 months

High-risk sexual behavior

Illicit drug use

Incarceration or a history of incarceration

Household members with active GI infection

Chronic constipation

Any gastrointestinal disorder

Overweight (BMI >25)

Obese (BMI >30)

Hypertension

Type 2 diabetes

Insulin sensitivity

Hyperlipidemi

Atherosclerosis

Malnutrition (BMI <18)

Autoimmune disease

Atopic disease

Psychiatric history

Infection with HIV, syphilis, hepatitis B or C

Malignancy

Chronic pain syndromes, neurologic or neurodevelopmental disorders

History of major gastrointestinal surgery

Any kind of liver disease

Alcoholic intake: No alcohol consumption

Family history of colorectal carcinoma

Family history of diabetes

Family history of early onset coronary disease, gastrointestinal or liver disease

Stool Tests

Ova, cysts, and parasites

Microscopy and culture

Rotavirus

Norovirus

Adenovirus

Clostridium difficile toxin

Vancomycin-resistantEnterococcus screen

Carbapenem-resistant Enterobacteriaceae

Extended spectrum β-lactamase-producing Enterobacteriaceae

Fecal Giardia antigen

Fecal Cryptosporidium antigen

Isospora

Cyclospora

Microsporidia

Blood Tests

Complete blood count

Electrolytes, urea, and creatinine

Liver function tests

Erythrocyte sedimentation rate

C-reactive protein

Fasting lipids and blood sugar level

Anti-TTG antibody for celiac disease

Antinuclear antibody

HIV type 1 and 2

Hepatitis A virus IgM

Hepatitis B virus surface antigen, hepatitis B virus core antibody (IgM and IgG), hepatitis B virus surface antibody

Hepatitis C virus antibody

Human T-cell lymphotropic virus 1 and 2

Epstein-Barr virus IgM

Cytomegalovirus IgM

Strongyloides stercoralis, Entamoeba histolytica, Helicobacter pylori serology

H pylori

Treponema pallidum screening cascade

Listeria

Nasal Swab

Methicillin-resistant Staphylococcus aureus

Urine Tests

Gonorrhea and chlamydia

Abbreviations: BMI, body mass index; GI, gastrointestinal; HIV, human immunodeficiency virus; Ig, immunoglobulin; TTG, tissue transglutaminase

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4.Tariq R,Weatherly ,Kammer P. et al.Donor screening experience for fecal microbiota transplantation in patients with recurrent C. difficile infection .J Clin Gastroenterol. 2016

OpenBiome.Quality and safety program.2017. Available at: http://www.openbiome.org/safety/. Accessed, 20 September 2017